| Item Type | Name |
|
Concept
|
Antibodies, Bacterial
|
|
Concept
|
Antigens, Ly
|
|
Concept
|
Agglutination Tests
|
|
Concept
|
alpha-Fetoproteins
|
|
Concept
|
Abelson murine leukemia virus
|
|
Concept
|
Adolescent
|
|
Concept
|
Adenine Nucleotides
|
|
Concept
|
Ampicillin Resistance
|
|
Concept
|
Binding Sites, Antibody
|
|
Concept
|
Bone Marrow Cells
|
|
Concept
|
Alleles
|
|
Concept
|
Amino Acid Sequence
|
|
Concept
|
Adult
|
|
Concept
|
Antibody Formation
|
|
Concept
|
Antigens
|
|
Concept
|
Antigens, Surface
|
|
Concept
|
Cell Communication
|
|
Concept
|
Cell Fractionation
|
|
Concept
|
Cell Line, Transformed
|
|
Concept
|
Animals
|
|
Concept
|
Antibody-Producing Cells
|
|
Concept
|
Antibodies, Anti-Idiotypic
|
|
Concept
|
Autoimmune Diseases
|
|
Concept
|
Ascitic Fluid
|
|
Concept
|
Antibody Specificity
|
|
Concept
|
Antigens, Bacterial
|
|
Concept
|
Histocompatibility Antigens Class II
|
|
Concept
|
B-Lymphocytes
|
|
Concept
|
Base Sequence
|
|
Concept
|
Cell Differentiation
|
|
Concept
|
Cell Movement
|
|
Concept
|
Autoantigens
|
|
Concept
|
Autoradiography
|
|
Concept
|
Chimera
|
|
Concept
|
Autoantibodies
|
|
Concept
|
Binding Sites
|
|
Concept
|
Bone Marrow
|
|
Concept
|
Cell Separation
|
|
Concept
|
Child
|
|
Concept
|
Carcinoma, Krebs 2
|
|
Concept
|
Biological Evolution
|
|
Concept
|
Clone Cells
|
|
Concept
|
Cell Transformation, Viral
|
|
Concept
|
Cell-Free System
|
|
Concept
|
Centrifugation, Density Gradient
|
|
Concept
|
Chromosome Deletion
|
|
Concept
|
Chromosome Mapping
|
|
Concept
|
Codon
|
|
Concept
|
Fungal Proteins
|
|
Concept
|
Genes, Immunoglobulin
|
|
Concept
|
Genetic Vectors
|
|
Concept
|
Coagulants
|
|
Concept
|
Guinea Pigs
|
|
Concept
|
Concanavalin A
|
|
Concept
|
Cosmids
|
|
Concept
|
Cross-Linking Reagents
|
|
Concept
|
Choline
|
|
Concept
|
Hematopoiesis
|
|
Concept
|
Homozygote
|
|
Concept
|
Cross Reactions
|
|
Concept
|
Immunoglobulin M
|
|
Concept
|
Immune System
|
|
Concept
|
DNA-Binding Proteins
|
|
Concept
|
Cytoplasm
|
|
Concept
|
Deoxyuracil Nucleotides
|
|
Concept
|
Dogfish
|
|
Concept
|
Immunoglobulin Constant Regions
|
|
Concept
|
Immunologic Deficiency Syndromes
|
|
Concept
|
Insulin
|
|
Concept
|
Cytidine
|
|
Concept
|
Cytidine Deaminase
|
|
Concept
|
DNA Repair
|
|
Concept
|
Cell Fusion
|
|
Concept
|
Chemotaxis, Leukocyte
|
|
Concept
|
Child, Preschool
|
|
Concept
|
DNA Mutational Analysis
|
|
Concept
|
DNA, Neoplasm
|
|
Concept
|
DNA, Recombinant
|
|
Concept
|
Electrophoresis, Polyacrylamide Gel
|
|
Concept
|
Hybridomas
|
|
Concept
|
Immunoglobulin A
|
|
Concept
|
Immunity, Active
|
|
Concept
|
Deoxyribonucleases
|
|
Concept
|
Cockayne Syndrome
|
|
Concept
|
DNA
|
|
Concept
|
DNA-Directed DNA Polymerase
|
|
Concept
|
DNA, Superhelical
|
|
Concept
|
Drug Stability
|
|
Concept
|
Fibrinogen
|
|
Concept
|
Fibroblasts
|
|
Concept
|
Introns
|
|
Concept
|
Ectoderm
|
|
Concept
|
Endonucleases
|
|
Concept
|
Enzyme Activation
|
|
Concept
|
Mice, Inbred C3H
|
|
Concept
|
Microtubule-Associated Proteins
|
|
Concept
|
Gene Expression Regulation
|
|
Concept
|
Deamination
|
|
Concept
|
Genes, Switch
|
|
Concept
|
Gene Conversion
|
|
Concept
|
Genes
|
|
Concept
|
Genes, MHC Class II
|
|
Concept
|
Kanamycin Resistance
|
|
Concept
|
Half-Life
|
|
Concept
|
Fluorides
|
|
Concept
|
DNA Polymerase III
|
|
Concept
|
Nucleic Acid Hybridization
|
|
Concept
|
Genetic Engineering
|
|
Concept
|
Histological Techniques
|
|
Concept
|
Hematopoietic Stem Cells
|
|
Concept
|
Embryo, Mammalian
|
|
Concept
|
DNA Replication
|
|
Concept
|
Immune Sera
|
|
Concept
|
Immune Tolerance
|
|
Concept
|
Immunoglobulin Heavy Chains
|
|
Concept
|
Enzyme-Linked Immunosorbent Assay
|
|
Concept
|
Herpesvirus 4, Human
|
|
Concept
|
Escherichia coli
|
|
Concept
|
Feedback
|
|
Concept
|
Flow Cytometry
|
|
Concept
|
Fluorescent Antibody Technique
|
|
Concept
|
Immunoglobulin Idiotypes
|
|
Concept
|
Immunoglobulin gamma-Chains
|
|
Concept
|
Immunoglobulin J-Chains
|
|
Concept
|
Multigene Family
|
|
Concept
|
Germ Cells
|
|
Concept
|
Goats
|
|
Concept
|
Leucine
|
|
Concept
|
Haploidy
|
|
Concept
|
Haptens
|
|
Concept
|
Macrophages
|
|
Concept
|
Isoelectric Point
|
|
Concept
|
Membrane Glycoproteins
|
|
Concept
|
Metallothionein
|
|
Concept
|
Laboratories
|
|
Concept
|
Mice, Inbred Strains
|
|
Concept
|
Models, Molecular
|
|
Concept
|
Mosaicism
|
|
Concept
|
Peyer's Patches
|
|
Concept
|
Mice, Inbred AKR
|
|
Concept
|
Mice, Transgenic
|
|
Concept
|
Models, Genetic
|
|
Concept
|
Nephrons
|
|
Concept
|
Plants
|
|
Concept
|
Poly U
|
|
Concept
|
Membranes
|
|
Concept
|
Exodeoxyribonucleases
|
|
Concept
|
Poultry
|
|
Concept
|
Pregnancy
|
|
Concept
|
Immunization, Secondary
|
|
Concept
|
Immunoglobulin Switch Region
|
|
Concept
|
Immunoglobulin Variable Region
|
|
Concept
|
Molecular Sequence Data
|
|
Concept
|
Molecular Weight
|
|
Concept
|
Neomycin
|
|
Concept
|
Mice, Inbred BALB C
|
|
Concept
|
Mice, Inbred C57BL
|
|
Concept
|
Middle Aged
|
|
Concept
|
Radiation Chimera
|
|
Concept
|
Recombination, Genetic
|
|
Concept
|
Repetitive Sequences, Nucleic Acid
|
|
Concept
|
Mutation
|
|
Concept
|
Cricetinae
|
|
Concept
|
Hot Temperature
|
|
Concept
|
Hemolysin Proteins
|
|
Concept
|
Peritoneum
|
|
Concept
|
Phosphorylcholine
|
|
Concept
|
Nucleosomes
|
|
Concept
|
Nucleic Acid Conformation
|
|
Concept
|
N-Glycosyl Hydrolases
|
|
Concept
|
Liver
|
|
Concept
|
Oocytes
|
|
Concept
|
Pedigree
|
|
Concept
|
Microcirculation
|
|
Concept
|
Microscopy, Electron
|
|
Concept
|
Phosphorus Isotopes
|
|
Concept
|
Plant Proteins
|
|
Concept
|
Poly A
|
|
Concept
|
Polyribosomes
|
|
Concept
|
Spermatids
|
|
Concept
|
Bacteriophage lambda
|
|
Concept
|
Phosphorylation
|
|
Concept
|
Muscle Proteins
|
|
Concept
|
Myeloma Proteins
|
|
Concept
|
Plasmacytoma
|
|
Concept
|
Osmolar Concentration
|
|
Concept
|
Female
|
|
Concept
|
Fetus
|
|
Concept
|
Pentosyltransferases
|
|
Concept
|
Proinsulin
|
|
Concept
|
Thymoma
|
|
Concept
|
Plasma Cells
|
|
Concept
|
Plasmids
|
|
Concept
|
Protein Precursors
|
|
Concept
|
Protein Binding
|
|
Concept
|
Protein Conformation
|
|
Concept
|
Proto-Oncogene Proteins
|
|
Concept
|
Proteins
|
|
Concept
|
Freund's Adjuvant
|
|
Concept
|
Genetic Markers
|
|
Concept
|
Hybrid Cells
|
|
Concept
|
Transcription Factors
|
|
Concept
|
Globins
|
|
Concept
|
Glycine
|
|
Concept
|
Immunoglobulin G
|
|
Concept
|
Image Processing, Computer-Assisted
|
|
Concept
|
Immune Complex Diseases
|
|
Concept
|
Immunization, Passive
|
|
Concept
|
Immunoelectrophoresis
|
|
Concept
|
Immunoglobulin Joining Region
|
|
Concept
|
Repressor Proteins
|
|
Concept
|
RNA-Directed DNA Polymerase
|
|
Concept
|
RNA, Neoplasm
|
|
Concept
|
Puromycin
|
|
Concept
|
Receptors, Antigen, B-Cell
|
|
Concept
|
Receptors, Immunologic
|
|
Concept
|
Writing
|
|
Concept
|
Xeroderma Pigmentosum
|
|
Concept
|
Interferon-gamma
|
|
Concept
|
Species Specificity
|
|
Concept
|
Gene Rearrangement, B-Lymphocyte
|
|
Concept
|
Regulatory Sequences, Nucleic Acid
|
|
Concept
|
Ribosomes
|
|
Concept
|
RNA Polymerase III
|
|
Concept
|
RNA Splicing
|
|
Concept
|
Leukemia, B-Cell
|
|
Concept
|
Spermatogonia
|
|
Concept
|
Research
|
|
Concept
|
RNA
|
|
Concept
|
RNA Polymerase II
|
|
Concept
|
Salmonella typhi
|
|
Concept
|
Hemocyanins
|
|
Concept
|
Histones
|
|
Concept
|
Sheep
|
|
Concept
|
Sulfites
|
|
Concept
|
Humans
|
|
Concept
|
Hypoxanthine Phosphoribosyltransferase
|
|
Concept
|
Immunity, Maternally-Acquired
|
|
Concept
|
Immunization
|
|
Concept
|
Time Factors
|
|
Concept
|
Transcription, Genetic
|
|
Concept
|
Transformation, Genetic
|
|
Concept
|
Protein Biosynthesis
|
|
Concept
|
Sulfur Radioisotopes
|
|
Concept
|
Stem Cells
|
|
Concept
|
Tritium
|
|
Concept
|
Immunoglobulin alpha-Chains
|
|
Concept
|
Immunoglobulin lambda-Chains
|
|
Concept
|
Immunoglobulin mu-Chains
|
|
Concept
|
Umbilical Veins
|
|
Concept
|
United States
|
|
Concept
|
Terminator Regions, Genetic
|
|
Concept
|
Immunoglobulin Class Switching
|
|
Concept
|
Kidney
|
|
Concept
|
Phosphotransferases (Alcohol Group Acceptor)
|
|
Concept
|
Myogenic Regulatory Factors
|
|
Concept
|
Lung
|
|
Concept
|
Lymphoid Tissue
|
|
Concept
|
Male
|
|
Concept
|
Mathematics
|
|
Concept
|
Tissue Extracts
|
|
Concept
|
Codon, Terminator
|
|
Concept
|
Gene Rearrangement
|
|
Concept
|
Gene Rearrangement, T-Lymphocyte
|
|
Concept
|
Trans-Activators
|
|
Concept
|
Peanut Agglutinin
|
|
Concept
|
Reverse Transcriptase Polymerase Chain Reaction
|
|
Concept
|
Tumor Cells, Cultured
|
|
Concept
|
Ultrafiltration
|
|
Concept
|
Chromosomes, Artificial, Bacterial
|
|
Concept
|
Valine
|
|
Concept
|
NF-kappa B
|
|
Concept
|
Deoxyribonucleases, Type II Site-Specific
|
|
Concept
|
B-Lymphocyte Subsets
|
|
Concept
|
Mutagenesis
|
|
Concept
|
Mice, Inbred DBA
|
|
Concept
|
TATA Box
|
|
Concept
|
3T3 Cells
|
|
Concept
|
Lymph Nodes
|
|
Concept
|
Lymphoma
|
|
Concept
|
Microinjections
|
|
Concept
|
Microscopy
|
|
Concept
|
Microsomes
|
|
Concept
|
Multiple Myeloma
|
|
Concept
|
Gene Rearrangement, B-Lymphocyte, Heavy Chain
|
|
Concept
|
Gene Rearrangement, B-Lymphocyte, Light Chain
|
|
Concept
|
DNA Probes
|
|
Concept
|
Gene Expression
|
|
Concept
|
Scientific Misconduct
|
|
Concept
|
Mutagenesis, Site-Directed
|
|
Concept
|
Sequence Alignment
|
|
Concept
|
Sequence Analysis, DNA
|
|
Concept
|
Protein Structure, Tertiary
|
|
Concept
|
Methionine
|
|
Concept
|
Methods
|
|
Concept
|
Methylation
|
|
Concept
|
Genes, Reporter
|
|
Concept
|
National Institutes of Health (U.S.)
|
|
Concept
|
Neoplasms, Experimental
|
|
Concept
|
Severe Combined Immunodeficiency
|
|
Concept
|
Point Mutation
|
|
Concept
|
Interferon-alpha
|
|
Concept
|
Bacteriophage P1
|
|
Concept
|
Apoptosis
|
|
Concept
|
Gene Deletion
|
|
Concept
|
Sequence Deletion
|
|
Concept
|
RNA Editing
|
|
Concept
|
Mice, Knockout
|
|
Concept
|
Gene Expression Regulation, Developmental
|
|
Concept
|
DNA, Complementary
|
|
Concept
|
Chemokines
|
|
Concept
|
Evolution, Molecular
|
|
Concept
|
Interferon-Stimulated Gene Factor 3
|
|
Concept
|
Interferon-Stimulated Gene Factor 3, gamma Subunit
|
|
Concept
|
Inhibitor of Apoptosis Proteins
|
|
Concept
|
Models, Immunological
|
|
Concept
|
Transgenes
|
|
Concept
|
BRCA1 Protein
|
|
Concept
|
Mice, Inbred MRL lpr
|
|
Concept
|
DNA-Activated Protein Kinase
|
|
Concept
|
Fanconi Anemia Complementation Group D2 Protein
|
|
Concept
|
Fas Ligand Protein
|
|
Concept
|
Artificial Gene Fusion
|
|
Concept
|
Base Pair Mismatch
|
|
Concept
|
Lymphocyte Count
|
|
Concept
|
Avian Proteins
|
|
Concept
|
CpG Islands
|
|
Concept
|
Nucleic Acid Denaturation
|
|
Concept
|
Protein Folding
|
|
Concept
|
Embryonic Development
|
|
Concept
|
Chromatin Assembly and Disassembly
|
|
Concept
|
Proto-Oncogene Proteins c-ets
|
|
Concept
|
Chromatin Immunoprecipitation
|
|
Concept
|
Proto-Oncogene Proteins c-bcl-2
|
|
Concept
|
5' Untranslated Regions
|
|
Concept
|
DNA Footprinting
|
|
Concept
|
Genes, bcl-2
|
|
Concept
|
Dendritic Cells, Follicular
|
|
Concept
|
Gene Expression Profiling
|
|
Concept
|
TATA-Box Binding Protein
|
|
Concept
|
bcl-X Protein
|
|
Concept
|
Saccharomyces cerevisiae Proteins
|
|
Concept
|
Polynucleotides
|
|
Concept
|
Promoter Regions, Genetic
|
|
Concept
|
Pseudomonas aeruginosa
|
|
Concept
|
Publishing
|
|
Concept
|
Mice
|
|
Concept
|
Ribonucleases
|
|
Concept
|
Ribosomal Proteins
|
|
Concept
|
Serine
|
|
Concept
|
RNA, Messenger
|
|
Concept
|
DNA Glycosylases
|
|
Concept
|
Tissue Distribution
|
|
Concept
|
Multiprotein Complexes
|
|
Concept
|
Interferon Regulatory Factors
|
|
Concept
|
Rats
|
|
Concept
|
TCF Transcription Factors
|
|
Concept
|
Culture Techniques
|
|
Concept
|
Uracil
|
|
Concept
|
Urea
|
|
Concept
|
Uridine
|
|
Concept
|
Spleen
|
|
Concept
|
Subcellular Fractions
|
|
Concept
|
Adaptor Proteins, Signal Transducing
|
|
Concept
|
Temperature
|
|
Concept
|
Blotting, Western
|
|
Concept
|
Chloramphenicol O-Acetyltransferase
|
|
Concept
|
Autoimmunity
|
|
Concept
|
MutS Homolog 2 Protein
|
|
Concept
|
Genes, myc
|
|
Concept
|
Thymosin
|
|
Concept
|
Lymphoma, B-Cell
|
|
Concept
|
Genes, RAG-1
|
|
Concept
|
Transfection
|
|
Concept
|
Viral Proteins
|
|
Concept
|
Blotting, Southern
|
|
Concept
|
Reproducibility of Results
|
|
Concept
|
Retroviridae Proteins, Oncogenic
|
|
Concept
|
Gene Expression Regulation, Enzymologic
|
|
Concept
|
Polymerase Chain Reaction
|
|
Concept
|
Zinc Fingers
|
|
Concept
|
Proliferating Cell Nuclear Antigen
|
|
Concept
|
DNA Methylation
|
|
Concept
|
Integrases
|
|
Concept
|
Leukocyte Common Antigens
|
|
Concept
|
Receptors, Chemokine
|
|
Concept
|
Gene Silencing
|
|
Concept
|
Chromosomes, Artificial
|
|
Concept
|
Gene Targeting
|
|
Concept
|
Homeodomain Proteins
|
|
Concept
|
Germinal Center
|
|
Concept
|
Microsatellite Repeats
|
|
Concept
|
Somatic Hypermutation, Immunoglobulin
|
|
Concept
|
DNA Mismatch Repair
|
|
Concept
|
Cytosine Deaminase
|
|
Concept
|
Uracil-DNA Glycosidase
|
|
Concept
|
Gene Knock-In Techniques
|
|
Concept
|
Antibodies
|
|
Concept
|
Antibody Diversity
|
|
Concept
|
Antigen-Antibody Reactions
|
|
Concept
|
Base Composition
|
|
Concept
|
Binding, Competitive
|
|
Concept
|
Blood Group Antigens
|
|
Concept
|
Carrier Proteins
|
|
Concept
|
Cell Line
|
|
Concept
|
Cells, Cultured
|
|
Concept
|
Chickens
|
|
Concept
|
Chromatin
|
|
Concept
|
Chromosomes
|
|
Concept
|
Cloning, Molecular
|
|
Concept
|
Crosses, Genetic
|
|
Concept
|
Cytosine
|
|
Concept
|
Deoxycytidine
|
|
Concept
|
Deoxyribonuclease I
|
|
Concept
|
Depression, Chemical
|
|
Concept
|
DNA Restriction Enzymes
|
|
Concept
|
DNA, Single-Stranded
|
|
Concept
|
Electrophoresis, Agar Gel
|
|
Concept
|
Enhancer Elements, Genetic
|
|
Concept
|
Erythrocytes
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Concept
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Hemagglutination Tests
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Concept
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Hemolytic Plaque Technique
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Concept
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Hypersensitivity, Delayed
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Concept
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Immunity
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Concept
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Immunoglobulins
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Concept
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Immunoglobulin kappa-Chains
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Concept
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Immunoglobulin Light Chains
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Concept
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Immunologic Memory
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Concept
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Kidney Tubules, Collecting
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Concept
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Kinetics
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Concept
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Genetic Linkage
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Concept
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Lymphocyte Activation
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Concept
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Lymphocytes
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Concept
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Mice, Mutant Strains
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Concept
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Microscopy, Phase-Contrast
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Concept
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Models, Biological
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Concept
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Neoplasm Proteins
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Concept
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Nuclear Proteins
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Concept
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Nucleotide Mapping
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Concept
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Organ Specificity
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Concept
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Peptides
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Concept
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Phenotype
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Concept
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Radiation Effects
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Concept
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Receptors, Antigen, T-Cell
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Concept
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Recombinant Fusion Proteins
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Concept
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RNA, Ribosomal
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Concept
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Spermatozoa
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Concept
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T-Lymphocytes
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Concept
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Thymus Gland
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Concept
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Translocation, Genetic
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Concept
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Umbilical Cord
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Concept
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Restriction Mapping
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Concept
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Deoxyribonuclease BamHI
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Concept
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Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor
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Concept
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Signal Transduction
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Concept
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Transcriptional Activation
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Concept
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Immunophenotyping
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Concept
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Tumor Suppressor Protein p53
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Concept
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Mutagenesis, Insertional
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Concept
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Mice, SCID
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Concept
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Sequence Analysis
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Concept
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DNA Primers
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Concept
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5-Methylcytosine
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Concept
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Macromolecular Substances
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Concept
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Proto-Oncogene Proteins c-bcl-6
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Concept
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Transcription Factor 7-Like 1 Protein
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Academic Article
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Lymphocyte development.
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Academic Article
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PU.1 is a component of a multiprotein complex which binds an essential site in the murine immunoglobulin lambda 2-4 enhancer.
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Academic Article
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Influence of CpG methylation and target spacing on V(D)J recombination in a transgenic substrate.
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Academic Article
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The mechanism of somatic hypermutation studied with transgenic and transfected target genes.
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Academic Article
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Somatic hypermutation of immunoglobulin genes is linked to transcription initiation.
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Academic Article
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N region diversity of a transgenic substrate in fetal and adult lymphoid cells.
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Academic Article
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Identification and characterization of the murine Rag1 promoter.
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Academic Article
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Progress in understanding the mechanism and consequences of somatic hypermutation.
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Academic Article
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Gamma 2b provides only some of the signals normally given via mu in B cell development.
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Academic Article
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Somatic hypermutation of an artificial test substrate within an Ig kappa transgene.
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Academic Article
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B lymphocytes of xeroderma pigmentosum or Cockayne syndrome patients with inherited defects in nucleotide excision repair are fully capable of somatic hypermutation of immunoglobulin genes.
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Academic Article
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The inactivation of the XP-C gene does not affect somatic hypermutation or class switch recombination of immunoglobulin genes.
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Academic Article
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Immunoglobulin transgenes as targets for somatic hypermutation.
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Academic Article
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The composition of coding joints formed in V(D)J recombination is strongly affected by the nucleotide sequence of the coding ends and their relationship to the recombination signal sequences.
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Academic Article
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Rearrangement and expression of immunoglobulin genes in transgenic mice.
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Academic Article
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Mef2 proteins, required for muscle differentiation, bind an essential site in the Ig lambda enhancer.
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Academic Article
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A linkage map of distal mouse chromosome 4 in the vicinity of Ssm1, a strain-specific modifier of methylation.
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Academic Article
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Cis-acting sequences that affect somatic hypermutation of Ig genes.
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Academic Article
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An efficient method for high-fidelity BAC/PAC retrofitting with a selectable marker for mammalian cell transfection.
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Academic Article
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Somatic hypermutation of immunoglobulin and non-immunoglobulin genes.
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Academic Article
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Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes.
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Academic Article
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A hypermutable insert in an immunoglobulin transgene contains hotspots of somatic mutation and sequences predicting highly stable structures in the RNA transcript.
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Academic Article
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Hypomethylation is necessary but not sufficient for V(D)J recombination within a transgenic substrate.
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Academic Article
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The TATA binding protein, c-Myc and survivin genes are not somatically hypermutated, while Ig and BCL6 genes are hypermutated in human memory B cells.
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Academic Article
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The role of DNA repair in somatic hypermutation of immunoglobulin genes.
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Academic Article
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A cis-acting element that directs the activity of the murine methylation modifier locus Ssm1.
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Academic Article
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Insertion of phosphoglycerine kinase (PGK)-neo 5' of Jlambda1 dramatically enhances VJlambda1 rearrangement.
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Academic Article
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Signal joint formation is inhibited in murine scid preB cells and fibroblasts in substrates with homopolymeric coding ends.
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Academic Article
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Effects of sequence and structure on the hypermutability of immunoglobulin genes.
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Academic Article
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Analysis of a T cell receptor gene as a target of the somatic hypermutation mechanism.
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Academic Article
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A novel cytidine deaminase affects antibody diversity.
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Academic Article
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A point mutation in the constant region of Ig lambda1 prevents normal B cell development due to defective BCR signaling.
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Academic Article
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Two conserved essential motifs of the murine immunoglobulin lambda enhancers bind B-cell-specific factors.
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Academic Article
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A novel cytidine deaminase AIDs in the delivery of error-prone polymerases to immunoglobulin genes.
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Academic Article
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The E box motif CAGGTG enhances somatic hypermutation without enhancing transcription.
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Academic Article
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Mutation pattern of immunoglobulin transgenes is compatible with a model of somatic hypermutation in which targeting of the mutator is linked to the direction of DNA replication.
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Academic Article
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Ig gene somatic hypermutation in mice defective for DNA polymerase delta proofreading.
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Academic Article
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Identification and localization of an enhancer for the human lambda L chain Ig gene complex.
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Academic Article
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Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled.
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Academic Article
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Immunology. Autoreactive B cells migrate into T cell territory.
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Academic Article
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Delay of early B-lymphocyte development by gamma 2b immunoglobulin transgene: effect on differentiation-specific molecules.
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Academic Article
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Scarcity of lambda 1 B cells in mice with a single point mutation in C lambda 1 is due to a low BCR signal caused by misfolded lambda 1 light chain.
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Academic Article
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Somatic hypermutation and class switch recombination in Msh6(-/-)Ung(-/-) double-knockout mice.
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Academic Article
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The published data.
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Academic Article
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The contested role of uracil DNA glycosylase in immunoglobulin gene diversification.
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Academic Article
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AID in somatic hypermutation and class switch recombination.
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Academic Article
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Targeting of the activation-induced cytosine deaminase is strongly influenced by the sequence and structure of the targeted DNA.
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Academic Article
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Expression of AID transgene is regulated in activated B cells but not in resting B cells and kidney.
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Academic Article
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A novel enhancer in the immunoglobulin lambda locus is duplicated and functionally independent of NF kappa B.
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Academic Article
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Alkyladenine DNA glycosylase (Aag) in somatic hypermutation and class switch recombination.
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Academic Article
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Differential splicing of thymosin beta 4 mRNA.
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Academic Article
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Transgenic mice with mu and kappa genes encoding antiphosphorylcholine antibodies.
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Academic Article
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The activation-induced cytidine deaminase (AID) efficiently targets DNA in nucleosomes but only during transcription.
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Academic Article
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A strain-specific modifier on mouse chromosome 4 controls the methylation of independent transgene loci.
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Academic Article
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Somatic hypermutation: processivity of the cytosine deaminase AID and error-free repair of the resulting uracils.
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Academic Article
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Brca1 in immunoglobulin gene conversion and somatic hypermutation.
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Academic Article
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Somatic hypermutation of an immunoglobulin transgene in kappa transgenic mice.
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Academic Article
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Analysis of somatic mutations in kappa transgenes.
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Academic Article
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Expression of immunoglobulin and globin genes in B and T lymphocytes and other cells.
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Academic Article
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Antibodies of different immunoglobulin classes released by single cells.
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Academic Article
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The switch region associated with immunoglobulin C mu genes is DNase I hypersensitive in T lymphocytes.
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Academic Article
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Asymmetric processing of coding ends and the effect of coding end nucleotide composition on V(D)J recombination.
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Academic Article
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Cloning of a gamma 2b gene encoding anti-Pseudomonas aeruginosa H chains and its introduction into the germ line of mice.
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Academic Article
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Alteration of the B cell surface phenotype, immune response to phosphocholine and the B cell repertoire in M167 mu plus kappa transgenic mice.
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Academic Article
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Elevated PC responsive B cells and anti-PC antibody production in transgenic mice harboring anti-PC immunoglobulin genes.
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Academic Article
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Antibody production by host cells in x-irradiated recipients of allogeneic spleen cells.
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Academic Article
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Quantitation of immunoglobulin genes by nucleic acid hybridization with RNA from myeloma and spleen microsomes.
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Academic Article
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Comparison of different rearranged immunoglobulin kappa genes of a myeloma by electronmicroscopy and restriction mapping of cloned DNA: implications for "allelic exclusion".
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Academic Article
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Allelic exclusion and control of endogenous immunoglobulin gene rearrangement in kappa transgenic mice.
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Academic Article
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Structural alterations in J regions of mouse immunoglobulin lambda genes are associated with differential gene expression.
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Academic Article
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Rearrangement of immunoglobulin genes.
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Academic Article
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Strain-specific transgene methylation occurs early in mouse development and can be recapitulated in embryonic stem cells.
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Academic Article
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Kinetics of mouse spleen cell populations during the immune response.
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Academic Article
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Analysis of immunoglobulin genes: DNA/RNA hybridization with immunoglobulin kappa-chain mRNA and isolation and translation of hybridized RNA.
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Academic Article
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Direct demonstration of immunoglobulin kappa chain RNA in thymus T cells by in situ hybridization.
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Academic Article
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Sequences related to immunoglobulin kappa chain messenger RNA in T cells.
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Academic Article
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Synthesis of specific RNA molecules during immune response in the mouse spleen.
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Academic Article
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Immunoglobulin genes in DNA restriction fragments.
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Academic Article
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Immunoglobulin gene 'remnant' DNA--implications for antibody gene recombination.
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Academic Article
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Somatic mutation of immunoglobulin light-chain variable-region genes.
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Academic Article
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Nucleosome stability dramatically impacts the targeting of somatic hypermutation.
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Academic Article
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Association of two different repetitive DNA elements near immunoglobulin light chain genes.
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Academic Article
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Gamma 2b transgenic mice as a model for the role of immunoglobulins in B cell development.
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Academic Article
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Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.
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Academic Article
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lambda 5, but not mu, is required for B cell maturation in a unique gamma 2b transgenic mouse line.
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Academic Article
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Expression, allelic exclusion and somatic mutation of mouse immunoglobulin kappa genes.
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Academic Article
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Transgenic mice with immunoglobulin genes.
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Academic Article
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The order and orientation of mouse lambda-genes explain lambda-rearrangement patterns.
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Academic Article
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Immunoglobulin messenger RNAs of T lymphocytes.
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Academic Article
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Fusion of a scid pre-B cells with a wild type (myeloma) B cell results in correct rearrangement of a V(D)J recombination substrate.
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Academic Article
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Lymphocyte development.
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Academic Article
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Antibody-carrying cells in the immune response 1. Identification of "rosette"-forming cells by light microscopy.
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Academic Article
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Heterogeneity of the 3' portion of sequences related to immunoglobulin kappa-chain mRNA.
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Academic Article
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Myeloma with multiple rearranged immunoglobulin kappa genes: only one kappa gene codes for kappa chains.
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Academic Article
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RNA sequences homologous to the 3' portion of immunoglobulin alpha-chain mRNA in thymus-derived lymphocytes.
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Academic Article
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Sequences of immunoglobulin lambda 1 genes in a lambda 1 defective mouse strain.
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Academic Article
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Evolution of mouse immunoglobulin lambda genes.
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Academic Article
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Expression of lambda and kappa genes can occur in all B cells and is initiated around the same pre-B-cell developmental stage.
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Academic Article
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Immunoglobulin gamma 2b transgenes inhibit heavy chain gene rearrangement, but cannot promote B cell development.
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Academic Article
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Attracting AID to targets of somatic hypermutation.
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Academic Article
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Number and activity of free and membrane-bound spleen ribosomes during the course of the immune response.
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Academic Article
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Ultrastructure of rosette-forming cells in the mouse during the antibody response.
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Academic Article
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Rearranged and germline immunoglobulin kappa genes: different states of DNase I sensitivity of constant kappa genes in immunocompetent and nonimmune cells.
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Academic Article
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Physical linkage of the constant region genes for immunoglobulins lambda I and lambda III.
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Academic Article
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Methylation patterns of immunoglobulin genes in lymphoid cells: correlation of expression and differentiation with undermethylation.
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Academic Article
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Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1.
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Academic Article
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The bulk chromatin structure of a murine transgene does not vary with its transcriptional or DNA methylation status.
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Academic Article
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Crossing the SJL lambda locus into kappa-knockout mice reveals a dysfunction of the lambda 1-containing immunoglobulin receptor in B cell differentiation.
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Academic Article
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Different mismatch repair deficiencies all have the same effects on somatic hypermutation: intact primary mechanism accompanied by secondary modifications.
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Academic Article
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The C(H)1 and transmembrane domains of mu in the context of a gamma2b transgene do not suffice to promote B cell maturation.
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Academic Article
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Molecular aspects of somatic hypermutation of immunoglobulin genes.
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Academic Article
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The 3' Igkappa enhancer contains RNA polymerase II promoters: implications for endogenous and transgenic kappa gene expression.
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Academic Article
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DNA polymerases in immunity: profiting from errors.
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Academic Article
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Immunoglobulin genes: generating diversity with AID and UNG.
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Academic Article
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The transcription factor Spi-B is not required for somatic hypermutation.
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Academic Article
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Steps in the generation of autoantibodies.
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Academic Article
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DNA methylation precedes chromatin modifications under the influence of the strain-specific modifier Ssm1.
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Academic Article
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Precursors of both conventional and Ly-1 B cells can escape feedback inhibition of Ig gene rearrangement.
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Academic Article
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The very 5' end and the constant region of Ig genes are spared from somatic mutation because AID does not access these regions.
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Academic Article
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Targeting of AID to immunoglobulin genes.
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Academic Article
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Inhibition of immunoglobulin gene rearrangement by the expression of a lambda 2 transgene.
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Academic Article
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The pattern of somatic hypermutation of Ig genes is altered when p53 is inactivated.
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Academic Article
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Physical linkage of mouse lambda genes by pulsed-field gel electrophoresis suggests that the rearrangement process favors proximate target sequences.
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Academic Article
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High-frequency deletional rearrangement of immunoglobulin kappa gene segments introduced into a pre-B-cell line.
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Academic Article
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Feedback inhibition of immunoglobulin gene rearrangement by membrane mu, but not by secreted mu heavy chains.
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Academic Article
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B cells expressing Ig transgenes respond to a T-dependent antigen only in the presence of Ia-compatible T cells.
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Academic Article
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Pre-B cells in kappa-transgenic mice.
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Academic Article
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Immunoglobulin gene rearrangements in hybridoma cells.
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Academic Article
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High expression of cloned immunoglobulin kappa gene in transgenic mice is restricted to B lymphocytes.
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Academic Article
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Mapping of immunoglobulin variable region genes: relationship to the 'deletion' model of immunoglobulin gene rearrangement.
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Academic Article
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Immunoglobulin synthesis by T cells: quantitative and qualitative aspects.
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Academic Article
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Evidence for multiple immunoglobulin genes.
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Academic Article
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Antibody-carrying cells in the immune response II. Ultrastructure of "rosette"-forming cells.
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Academic Article
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Changes in RNA polymerase II progression influence somatic hypermutation of Ig-related genes by AID.
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Academic Article
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Turnover of myeloma messenger DNA.
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Academic Article
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Influence of metabolic inhibitors on the capacity of spleen cells to form hemolytic plaques and rosettes.
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Academic Article
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[FETAL FIBRINOGEN. IV. STUDIES ON THE IMMUNOLOGICAL AND PHYSICO-CHEMICAL BEHAVIOR OF FETAL FIBRINOGEN].
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Academic Article
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Dissent on forensic evidence.
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Academic Article
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Why does somatic hypermutation by AID require transcription of its target genes?
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Academic Article
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Identification of Ssm1b, a novel modifier of DNA methylation, and its expression during mouse embryogenesis.
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Academic Article
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The central vessel of the renal countercurrent bundles of two marine elasmobranchs--dogfish (Scyliorhinus caniculus) and skate (Raja erinacea)--as revealed by light and electron microscopy with computer-assisted reconstruction.
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Academic Article
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Delayed hypersensitivity in vitro.
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Academic Article
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Ssm1b expression and function in germ cells of adult mice and in early embryos.
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Concept
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Embryonic Germ Cells
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Concept
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MutL Protein Homolog 1
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Concept
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MEF2 Transcription Factors
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Concept
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In Vitro Techniques
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Grant
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Molecular and Cellular Biology Training
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Grant
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CONTROL OF IMMUNOGLOBULIN SYNTHESIS
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Grant
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CONTROL OF IMMUNOGLOBULIN SYNTHESIS
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Grant
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EXPRESSION OF IMMUNOGLOBULIN GENES IN TRANSGENIC MICE
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Grant
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CONTROL OF IMMUNOGLOBULIN SYNTHESIS
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Grant
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MUTATION OF IG GENES
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Grant
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T LYMPHOCYTE SPECIFIC GENES
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Grant
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Mechanism of Immunoglobulin Hypermutation
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Grant
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AID in somatic mutation of immunoglobulin genes
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Grant
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Mechanism of Immunoglobulin Hypermutation
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Grant
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Immunoglobulin Somatic Mutation
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Grant
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Identification of the DNA methylation/chromatin modifier Ssm1
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Grant
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EXPRESSION OF IMMUNOGLOBULIN GENES
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